Abstract: Eugenia dysenterica is a Brazilian tree investigated for its properties and bioactive compounds, which are believed to have both pharmacological and phytochemical therapeutic effects. The leaves of this tree contain tannins, flavonoids, terpenes, and saponins, with reportedly beneficial effects to the human body. Despite these therapeutic applications, its effects have never been tested on oral tissues. Therefore, the aim of the present study was to evaluate the cytotoxic and antioxidant effects and the anti-inflammatory and repair properties of the acetone fraction of E. dysenterica on primary culture of human gingival fibroblasts and on the immortalized murine macrophage cell line (RAW 264.7). For this purpose, a metabolic activity assay, a wound healing assay, a nitric oxide assay, and RT-qPCR were performed. The assays revealed a cytoprotective effect of this plant, suggested by the increase in the expression of SOD1 and NRF2. An antioxidant potential effect was observed in the DPPH• assay. However, the fraction of E. dysenterica did not show anti-inflammatory activity. In conclusion, Eugenia dysenterica may promote cytoprotection when associated with chlorhexidine digluconate because of its antioxidant effect. However, additional studies are necessary on other human dental tissues using other parts of the plant in order to develop a possible mouthwash to assist patients with oral disorders.

INTRODUÇÃO: A visível exaustão do modelo tradicional na formação do fisioterapeuta, a proposição de um novo perfil profissional e a mudança na abordagem no processo saúde-doença, que passa a observar a funcionalidade, vem estimular a necessidade de novos projetos pedagógicos para o ensino da fisioterapia. Este deve incluir uma perspectiva de transformação social e econômica da população regional, nesse caso o da região administrativa de Ceilândia, no Distrito Federal. OBJETIVO: Apresentar uma proposta de projeto pedagógico para curso de graduação em fisioterapia, valorizando a formação focada na funcionalidade humana em cenários de prática profissional propostos pelo Sistema Único Saúde (SUS). RESULTADOS: O currículo está sendo construído numa perspectiva inovadora com propostas no âmbito geral (núcleos modo de vida, sistemas biológicos, instrumentalização em fisioterapia e cenários das práticas em fisioterapia); no âmbito específico (manutenção da saúde, processo saúde-doença, atenção à saúde, funcionalidade humana, processo permanente de formação); e no âmbito complementar (atividades de pesquisa e extensão). A proposta de projeto pedagógico foi pensada de forma a contemplar os objetivos gerais e específicos esperados, bem como dos perfis profissional e social. A indissociabilidade do ensino-pesquisa-extensão assume uma referência na relação professor-estudante pela compreensão das atividades de pesquisa e extensão como elementos fundamentais do processo ensino-aprendizagem vinculado à vivência no contexto real, concretizando a relação teoria e prática, e com foco no SUS. CONCLUSÃO: A diversificação das práticas no contexto do SUS inclui uma perspectiva de transformação social e econômica da população no cenário social e político do Distrito Federal. Nesse contexto, prioriza-se a formação do profissional fisioterapeuta generalista, reflexivo e crítico, envolvido desde o princípio com o atendimento à comunidade nos diferentes níveis de atenção, voltado aos aspectos da funcionalidade humana.

INTRODUCTION: The visible exhaustion of the traditional teaching model for physiotherapy, along with a new professional profile and a change in the approach to the health-illness process (which has come to include functionality), has stimulated the need for new pedagogical projects for teaching physiotherapy. This should include a perspective of social and economic transformation of the regional population (in this case, the administrative region of Ceilândia, in the Federal District, Brasília, Brazil). OBJECTIVE: To present a pedagogical project for the undergraduate course in physiotherapy stressing education focused on human functionality in scenarios of professional practice,e proposed by the Brazilian public healthcare system. METHODS: The curriculum is being constructed in an innovating perspective with proposals regarding the general realm (lifestyle centers, biological systems, physiotherapy skills and scenarios of physiotherapy practices), specific realm (health maintenance, health-illness process, healthcare, human functionality, process of permanent education) and complementary realm (research and extension activities). RESULTS: The pedagogical project proposal was carried out in such a way as to complement the expected general and specific goals as well as professional and social profiles. The indissociability of teaching-research-extension presumes a reference in the professor-student relationship for the comprehension of research and extension activities as fundamental elements of the teaching-learning process linked to experience in the actual context, thereby concretizing the relationship between theory and practice, focusing on the public healthcare system. CONCLUSION: The diversification of practices in the context of the public healthcare system includes a perspective of social and economic transformation in the population within the social and political scenario of the Federal District. In this context, priority is given to the education/training of generalist, reflexive, critical physiotherapists, involved from the beginning with community service on different levels of healthcare, addressing aspects of human functionality in accordance with the needs of the Brazilian public healthcare system.